Synthesis and biological activities of methylenebis-4$H$-1,2,4-triazole derivatives

Synthesis and biological activities of methylenebis-4H -1,2,4-triazole derivatives

Abstract: 5,5 ′ -Methylenebis(4–phenyl-4H -1,2,4-triazole-3-thiol) (2) was synthesized starting from hydrazinecarbothioamide compound (1). Treatment of compound 2 with ethyl bromoacetate produced diethyl 5,5 ′ -{methylenebis[(4phenyl-4H -1,2,4-triazole-5,3-diyl)thio]}diacetate (3), which was converted to the corresponding diacetohydrazide derivative (4) by treatment with hydrazine hydrate. The ...

Synthesis and antimicrobial activities of some new 1,2,3-triazole derivatives.

Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbonylhydrazones (1a-e) with several primary amines. The synthesis of 4-amino-5-(4-chlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (13)...

Synthesis and biological screening of 1,2,4-triazole derivatives

A series of 2-((arylamino)methyl)-5-(3-methoxyphenyl)-1-phenyl-1H-1,2,4-triazole-3-thione derivatives have been synthesized and characterized by FT-IR, NMR, mass spectral and elemental analysis. Compounds (MM4a-m) have been evaluated for their in vitro antibacterial activity against selected gram-positive and gram-negative bacteria and in vitro antifungal activity against fungal pathogens by us...

Synthesis and Biological Evaluation of Some Novel Triazole Derivatives

A series of eighteen novel 2-[(4-amino-5pyridin-3-yl-4H-1,2,4-triazol-3-yl)thio]-N-(substituted phenyl) propanamides 3(a-i) and 2-[(4-amino-5-phenyl-4H-1,2,4-triazol-3-yl) thio]-N-(substituted phenyl) propanamides 5(a-i) were synthesized by reacting 4-amino-5-pyridin-3-yl-4H-1,2,4-triazole-3-thiol (2) and 4-amino-5-phenyl-4H1,2,4-triazole-3-thiol (4) with the respective 2-chloro-N-(substituted ...

Synthesis, Characterization Biological Screening of Some Novel Triazole Derivatives